Arthritis Home > Ponstel

Ponstel is a prescription drug that is used to help relieve mild to moderate pain. The medication works by blocking the effects of certain pain-causing hormones in the body, which helps to reduce pain related to bone, muscle, or tendon injury or inflammation. This drug can also help decrease uterine contractions. Potential side effects of Ponstel may include headache, dizziness, constipation, and diarrhea.

What Is Ponstel?

Ponstel® (mefenamic acid) is a prescription medicine used for the relief of mild to moderate pain, including painful menstrual periods. Ponstel is in a class of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs for short.
(Click What Is Ponstel Used For? for more information on these uses, along with possible off-label uses for Ponstel.)

Who Makes Ponstel?

Ponstel is manufactured by Shionogi, Inc.

How Does It Work?

Ponstel and other NSAIDs are thought to work by inhibiting the action of certain hormones that cause inflammation and pain in the body. These hormones are called prostaglandins.


By blocking the effects of prostaglandins, Ponstel is useful at reducing pain related to bone, muscle, or tendon injury or inflammation and decreasing uterine contractions.

When and How Do I Take It?

Some general considerations for when and how to take Ponstel include:
  • The medication comes in capsule form.
  • It should be taken with food and a full glass of water.
  • For Ponstel to work properly, you have to take it as prescribed. It will not work if you stop taking it.
  • It is important to take the lowest effective dose for the least amount of time in order to treat your condition. This will decrease the chances of developing serious side effects.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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