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Simponi Uses for Ulcerative Colitis

Ulcerative colitis is a type of inflammatory bowel disease (IBD) that leads to inflammation and sores in the lining of the large intestine and rectum. It commonly causes abdominal pain, diarrhea, and other symptoms, like rectal bleeding or extreme urgency to have a bowel movement. At this time, the causes of ulcerative colitis are not fully understood. Although associated complications can be quite severe, there is only one cure -- surgery.
Other than surgery (see Ulcerative Colitis Surgery), treatment options include the following:
Simponi is approved to treat moderate-to-severely active ulcerative colitis in adults who are dependent on steroids to control their symptoms or who have had an inadequate response to or have failed to tolerate certain other ulcerative colitis medications. It is used both to "induce remission" (to cause the disease to at least temporarily go away) and to "maintain remission" (to keep it from coming back).

How Does Simponi Work?

Simponi belongs to a group of drugs called tumor necrosis factor (TNF) blockers. There are different types of TNF, and Simponi binds preferentially to TNF-alpha. TNF-alpha is a naturally occurring chemical in the body that is involved in inflammation and other immune system functions. It can contribute to various diseases by encouraging inflammation.
Blocking TNF-alpha helps to decrease the inflammation and to relieve the signs and symptoms of ankylosing spondylitis, psoriatic arthritis, ulcerative colitis, and rheumatoid arthritis.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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