Arthritis Home > Simponi

Available by prescription, Simponi is a medication licensed to treat ankylosing spondylitis and certain other inflammatory conditions. It is injected once a month; you can give yourself the injection or have a healthcare provider or caregiver administer it for you. Possible side effects include high blood pressure and skin redness at the site of the injection.

What Is Simponi?

Simponi™ (golimumab) is a prescription medication approved to treat the following conditions:
 
It is injected just under the skin once per month.
 
(Click Simponi Uses for more information on this topic, including possible off-label uses.)
 

Who Makes It?

Simponi is made by Centocor Ortho Biotech, Inc.
 

How Does Simponi Work?

Simponi belongs to a group of drugs called tumor necrosis factor (TNF) blockers. There are different types of TNF, and Simponi binds preferentially to TNF-alpha. TNF-alpha is a naturally occurring chemical in the body that is involved in inflammation and other immune system functions.
 
TNF-alpha can contribute to various diseases by encouraging inflammation. Blocking it helps to decrease the inflammation and to relieve the signs and symptoms of ankylosing spondylitis, psoriatic arthritis, ulcerative colitis, and rheumatoid arthritis.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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