Arthritis Home > Drug Interactions With Sulindac

When certain medications are taken together, it is possible to develop drug interactions. With sulindac, some of the medications that can lead to interactions include angiotensin II receptor blockers, cyclosporine, and other nonsteroidal anti-inflammatory drugs. Besides decreasing the medicines' effectiveness, these interactions may cause side effects such as kidney damage, bleeding, or stomach ulcers. If drug interactions are a concern in your situation, your healthcare provider may adjust your dosages or monitor you more closely.

Interactions With Sulindac: An Overview

Sulindac (Clinoril®) can potentially interact with several different medicines. Some of these medications include the following:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with sulindac and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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