Arthritis Home > Tylenol Drug Interactions

Alcohol, cholestyramine, or barbiturates can all cause drug interactions with Tylenol. Many of these medications can affect the way your body handles Tylenol, making both drugs less effective and more toxic. Interactions may also occur if you take other products containing acetaminophen (the active ingredient in Tylenol); you should not take more than 4000 mg total of acetaminophen per day.

Tylenol Interactions: An Overview

Tylenol® (acetaminophen) can potentially interact with other medications. Some of the medicines that may lead to drug interactions with Tylenol include:
 
  • Alcohol
  • Barbiturates, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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