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Uloric is a prescription medicine used for preventing gout attacks. Because of the way it works, this medication is not very effective for treating a gout attack that is already occurring. By inhibiting the effects of a certain enzyme in the body, the drug can lower uric acid levels. This medication comes in tablet form and is typically taken once a day. Side effects include nausea, joint pain, and gout flares.

What Is Uloric?

Uloric® (febuxostat) is a prescription medication approved for the treatment of gout. It is the first new medication approved for gout in the past 40 years.
(Click Uloric Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Uloric is made by Takeda Pharmaceuticals America, Inc.

How Does It Work?

Uloric works by lowering uric acid levels. This helps to treat gout, as gout is caused when the levels of uric acid become so high that uric acid crystals form inside the joint. The medication lowers uric acid levels by inhibiting xanthine oxidase, an enzyme responsible for producing uric acid in the body. By inhibiting xanthine oxidase, Uloric slows down the rate at which the body produces uric acid.
Uloric works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, Uloric is usually taken along with other gout medications, at least temporarily.

Uloric Effects

Studies have consistently shown that Uloric lowers uric acid levels in the blood more effectively than allopurinol (Zyloprim®), a similar medication that has been used to treat gout for decades. For instance, one study looked at the percentage of people who were able to lower their uric acid levels to 6 mg/dL or lower. As many as 74 percent of people taking Uloric 80 mg achieved this goal, compared to just 36 percent of people who were taking allopurinol.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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