Vimovo is approved for the treatment of several conditions, including osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is a combination medication -- it works to relieve pain and inflammation, but it also helps prevent stomach ulcers. This prescription medication comes in the form of extended-release tablets and is typically taken twice daily. Possible side effects include heartburn and diarrhea.
(Click Vimovo Uses for more information on what the medication is used for, including possible off-label uses.)
Who Makes This Medication?
Vimovo is made by Patheon Pharmaceuticals, Inc., for AstraZeneca, LP.
How Does Vimovo Work?
Vimovo contains two different active ingredients. Naproxen belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). Like other NSAIDs, it works by blocking a specific enzyme known as cyclooxygenase (COX), blocking the production of various inflammatory substances in the body.
The other active ingredient (esomeprazole) belongs to a group of medications called proton pump inhibitors (PPIs). The stomach contains tiny pumps (called proton pumps) that produce acid. Esomeprazole works by binding to the proton pumps, stopping them from producing acid. PPIs are very effective at decreasing acid production, as they work directly at the acid pumps.
Naproxen is very effective, but many people cannot take naproxen because it has a tendency to cause stomach ulcers. Esomeprazole is added to Vimovo to help reduce the risk for ulcers.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Vimovo [package insert]. Deerfield, IL: Horizon Pharma USA, Inc.;2014 February.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed December 16, 2010.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed December 16, 2010.
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