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Your specific Xarelto dosage will depend on the reason you are taking it, your kidney function, and other factors. The standard dose for preventing blood clots after surgery is typically 10 mg once daily. However, if you have kidney problems, you may need a lower amount.

An Introduction to Dosing With Xarelto

The dose of Xarelto® (rivaroxaban) your healthcare provider recommends will vary, depending on several factors, such as:
  • The reason you are taking Xarelto
  • The type of surgery you had (for use after surgery)
  • Whether you are taking any medications that could interact with Xarelto
  • How well your kidneys are functioning. 


As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.


Standard Xarelto Dosage After Surgery

The standard Xarelto dose for preventing blood clots in people undergoing knee replacement or hip replacement surgery is 10 mg once daily. The first dose is given at least 6 to 10 hours after surgery, once all bleeding is under control. The drug is usually continued for 12 days (for knees) or for 35 days (for hips). At this low dosage, it does not matter if you take the medication with or without food.

Standard Xarelto Dosage for Atrial Fibrillation

The standard Xarelto dose for preventing blood clots and strokes in people with atrial fibrillation is 20 mg once daily with the evening meal. If your kidneys are not functioning as well as they normally should, a lower dosage (15 mg once daily with the evening meal) may be recommended. If you have severe kidney problems, this drug may not be appropriate for you.

Standard Xarelto Dosage for Treating Blood Clots

The standard Xarelto dose for treating blood clots (either deep vein thrombosis or pulmonary embolism) is 15 mg twice a day, with food. After 21 days, you can be switched to a lower dosage of 20 mg once daily with food. Your healthcare provider will decide how long you should be treated, as continued treatment helps to prevent future blood clots. 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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