Arthritis Home > Zydone Drug Interactions

If certain medications are combined with Zydone, drug interactions could occur that may significantly increase your risk for serious side effects, such as extreme drowsiness, confusion, or liver failure. Products that can interact with Zydone include alcohol, barbiturates, and other medicines that contain acetaminophen. To prevent these and other drug interactions, talk to your healthcare provider before combining Zydone with any other medications.

Zydone Drug Interactions: An Overview

Zydone® (hydrocodone/APAP) can potentially interact with a number of other medications. In particular, Zydone is prone to interacting with other medications that cause drowsiness or sedation. Some of the medicines that may lead to drug interactions with Zydone include:
  • Alcoholic beverages (or medications that contain alcohol)
  • Antidepressants
  • Antihistamines (including many allergy, sleep, and motion sickness medications)
  • Antipsychotics
  • Barbiturate medications, such as:
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
  • Other opiates or narcotics, such as morphine (MS Contin®, MSIR®) or oxycodone (OxyIR®, OxyContin®)
  • Other products that contain acetaminophen, including many prescription and non-prescription pain killers and cold or cough products
  • Sleep medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation




Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.