Arthritis Home > Zydone Warnings and Precautions
Being aware of warnings and precautions with Zydone can help ensure a safe treatment process. For example, you should not drive or operate heavy machinery until you know how the drug affects you, and people with liver or kidney disease may not be able to take Zydone. Warnings and precautions also apply to women who are pregnant or breastfeeding.
Zydone: What Should I Tell My Healthcare Provider?Talk with your healthcare provider prior to taking Zydone® (hydrocodone/APAP) if you have:
- A history of drug or alcohol dependence
- Severe abdominal (stomach) pain
- A head injury or high intracranial pressure
- Liver disease, such as cirrhosis, liver failure, or hepatitis
- An enlarged prostate (benign prostatic hyperplasia, or BPH)
- Lung disease of any sort
- Addison's disease
- Kidney disease, such as kidney failure (renal failure)
- Any allergies, including allergies to foods, dyes, or preservatives.
- Pregnant or thinking of becoming pregnant
Specific Zydone Warnings and PrecautionsPrecautions and warnings to be aware of prior to taking Zydone include the following:
- The medication can cause problems in people with head injuries or high intracranial pressure. Zydone should only be used with extreme caution in such circumstances.
- Zydone contains quite a bit of acetaminophen (Tylenol®). Taking too much Zydone, or taking it in combination with other products that contain acetaminophen, can cause severe liver problems or even death due to Tylenol poisoning. Zydone may not be a good choice for people who already have liver disease.
- Zydone can potentially interact with several other medications (see Zydone Drug Interactions).
- Zydone is a narcotic medication with significant potential for abuse. It is not a good choice for people who have a history of alcohol or drug abuse. Do not take the drug more frequently, longer, or at a higher dose than prescribed. If you feel you may be developing a problem with Zydone abuse, please seek help from your healthcare provider.
- The medication can cause slow and irregular breathing. In severe situations, this may be life-threatening. This may be especially dangerous in people with lung problems.
- Do not drive or operate heavy machinery until you know how Zydone affects you. Your reflexes and reaction times may be significantly affected, even if you feel fine.
- Narcotics such as Zydone are likely to cause constipation. This side effect does not go away as you continue to take the drug. Usually, laxatives are necessary to treat and prevent constipation due to Zydone.
- The medication can interfere with the diagnosis of many conditions that cause severe abdominal (stomach) pain.
- Like any other narcotic, Zydone can cause dizziness and drowsiness, and may increase the risk of falls in elderly people.
- Check with your healthcare provider before taking the drug if you have hypothyroidism, Addison's disease, an enlarged prostate, or kidney disease, as Zydone may not be the best choice for you.
- Zydone is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Zydone and Pregnancy).
- Zydone passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Zydone and Breastfeeding).