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Zydone contains two different substances: a pain reliever and a narcotic. As a result, the drug is effective at treating moderate to somewhat severe pain. It is available in tablet form, and is typically taken as needed for pain or every four to six hours. Follow your dosing guidelines carefully, as too much Zydone can lead to liver failure.

What Is Zydone?

Zydone® (hydrocodone/APAP) is a prescription pain medication. As a narcotic, it is classified as a controlled substance, which means that special regulations and laws control its sale and use. Zydone is approved to treat moderate to moderately severe pain.
(Click Zydone Uses for more information, including possible off-label uses.)

How Does Zydone Work?

Zydone contains two different medications: acetaminophen and hydrocodone bitartrate. Acetaminophen ("APAP") is a pain reliever and fever reducer commonly found in nonprescription medications such as Tylenol®. APAP is an acronym for one of the chemical names of acetaminophen.
Hydrocodone is a semi-synthetic narcotic opioid pain reliever. It is similar to codeine. Hydrocodone is effective at decreasing pain and relieving coughing, but also causes drowsiness, mood changes, and mental "clouding."
In the United States, hydrocodone is only available in combination with other medications; it is not available alone. Combining it with acetaminophen helps improve Zydone's effectiveness at relieving pain.

Who Makes Zydone?

Zydone is made by Endo Pharmaceuticals, Inc.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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