Taking Nabumetone With Other Medicines

Diuretics
Combining nabumetone with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking nabumetone and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining nabumetone with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine nabumetone with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Nabumetone may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Combining probenecid and nabumetone may increase the levels of nabumetone in the blood. Therefore, your healthcare provider may recommend a lower nabumetone dosage and monitor you more closely.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with nabumetone may increase the risk of bleeding. Check with your healthcare provider before taking nabumetone with an SSRI or SNRI.
 
Herbal and/or Nutritional Supplements
Several herbal and nutritional supplements can also interact with nabumetone and may increase the risk of bleeding. If you are taking any natural or herbal supplements, make sure to discuss this with your healthcare provider before starting nabumetone therapy.
  
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