Drug Interactions With Nabumetone

Nabumetone has been known to interact with a number of medications, such as aspirin, lithium, and other nonsteroidal anti-inflammatory drugs (NSAIDs). Nabumetone interactions can lead to problems such as an increased risk of kidney damage and decreased effectiveness of diuretics and ACE inhibitors. Warfarin, methotrexate, and cyclosporine are among the other drugs that nabumetone can potentially interact with.

Nabumetone Tablets

Interactions With Nabumetone: An Introduction

Nabumetone (Relafen^®) can potentially interact with a number of medicines. Examples of these medications include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), naproxen (Aleve^®, Anaprox^®, Naprosyn^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), etodolac (Lodine^®, Lodine XL), meloxicam (Mobic^®), and others
Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), or ramipril (Altace^®)
Methotrexate (Rheumatrex^®, Trexall^™)
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others.

Several herbal and nutritional supplements can also interact with nabumetone and may increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Drug Interactions With Nabumetone Continued: Page 2)