Drug Interactions With Nabumetone

Drug interactions with nabumetone can increase the risk of kidney damage, as well as decrease the effectiveness of diuretics and ACE inhibitors. Nabumetone can also interact with other nonsteroidal anti-inflammatory drugs (NSAIDs) -- including indomethacin, naproxen, and diclofenac -- to increase your risk of bleeding. Warfarin, methotrexate, and cyclosporine are among the other drugs that nabumetone can potentially interact with.

 

Drug Interactions With Nabumetone: An Introduction

Nabumetone (Relafen®) can potentially interact with a number of medicines. Some of these drug interactions with nabumetone include:
 

 

Several herbal and nutritional supplements can also interact with nabumetone and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Warfarin (Coumadin, Jantoven)
If you are taking other blood thinners (such as warfarin) while taking nabumetone, your body may metabolize them differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
(Drug Interactions With Nabumetone Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;