Naprelan can potentially interact with other nonsteroidal anti-inflammatory drugs (NSAIDs), as well as warfarin and diuretics like furosemide and hydrochlorothiazide. Among other things, drug interactions can change the way your body metabolizes the medicines, alter the levels of the drugs in your body, and make some drugs less effective. Be sure to talk with your healthcare provider or pharmacist about any drug interactions with Naprelan that may apply to you.
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with Naprelan and may increase the risk of bleeding. Examples of these include, but are not limited to: