Naprelan Drug Interactions

Naprelan can potentially interact with other nonsteroidal anti-inflammatory drugs (NSAIDs), as well as warfarin and diuretics like furosemide and hydrochlorothiazide. Among other things, drug interactions can change the way your body metabolizes the medicines, alter the levels of the drugs in your body, and make some drugs less effective. Be sure to talk with your healthcare provider or pharmacist about any drug interactions with Naprelan that may apply to you.

Naprelan Medicine

An Overview of Naprelan Interactions

Naprelan^® (naproxen sodium) can potentially interact with a number of medicines. Some of the drugs that can cause an interaction include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), nabumetone (Relafen^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), meloxicam (Mobic^®), etodolac (Lodine®), ketoprofen, ketorolac (Toradol^®), and others
Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), or ramipril (Altace^®)
Methotrexate (Rheumatrex^®, Trexall^™)
Cholestyramine (Prevalite^®, Questran^®, Questran^® Light, LoCholest^®)
Beta blockers, such as metoprolol (Lopressor^®), propranolol (Inderal^®), atenolol (Tenormin^®), and metoprolol (Toprol XL^®)
Probenecid (Benemid^®, Probalan^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others.

Several herbal and nutritional supplements can also interact with Naprelan and may increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Naprelan Drug Interactions Continued: Page 2)