Specific Drugs That Interfere With Naproxen Sodium

Interactions With Naproxen Sodium Explained

The following sections explain how the drugs mentioned above can interact in a negative fashion when taken with naproxen sodium.
 
ACE Inhibitors
Combining naproxen sodium with an ACE inhibitor can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ACE inhibitor for lowering blood pressure.
 
ARBs
Combining naproxen sodium with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.
 
Beta Blockers
Combining naproxen sodium with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to naproxen sodium in the digestive tract and delay its absorption into the body. To avoid this drug interaction, naproxen sodium should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
 
Corticosteroids
Using corticosteroids with naproxen sodium can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
 
Cyclosporine
Naproxen sodium may increase the level of cyclosporine in the blood, increasing the risk of serious side effects of cyclosporine. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
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