Naproxen Sodium Drug Interactions

When certain medicines are taken with naproxen sodium, drug interactions may develop. Drugs that can potentially cause an interaction include methotrexate, diuretics, beta blockers, and ACE inhibitors. Your body may metabolize these drugs differently than intended, and side effects may occur, such as stomach ulcers or increased risk of bleeding. Some interactions may also increase the level of medicine in your blood.

Naproxen Sodium Medicine

Naproxen Sodium Interactions: An Overview

Naproxen sodium (brand names include Aleve^®, Anaprox^®, and Naprelan^®) can potentially interact with several different medicines. Some of the medicines that can cause drug interactions with naproxen sodium include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

Ketoprofen, ketorolac (Toradol^®)

Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as:

Ramipril (Altace^®)

Methotrexate (Rheumatrex^®, Trexall™)
Cholestyramine (Prevalite^®, Questran^®, Questran^®Light, LoCholest^®)
Beta blockers, such as metoprolol (Lopressor^®), propranolol (Inderal^®), atenolol (Tenormin^®), and metoprolol (Toprol XL^®)
Probenecid (Benemid^®, Probalan^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others.

Several herbal and nutritional supplements can also interact with naproxen sodium and may increase the risk of bleeding. Examples of these include but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Naproxen Sodium Drug Interactions Continued: Page 2)