Naproxen and Alcohol
Although many people may be able to combine naproxen and alcohol without any problems, this combination could cause serious problems for some people. For instance, consuming alcohol while on this drug can increase your risk of ulcers and bleeding in the stomach and intestines (or make these problems worse). Also, you should not combine the two if you have liver disease.
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There are a few reasons why you might want to avoid alcohol (or at least limit your alcohol consumption) while taking naproxen (Aleve®, Anaprox®, Naprosyn®, Naprelan®). While many people may be able to combine naproxen and alcohol without any consequences, some people may experience serious problems.
Two different problems may occur when naproxen is combined with alcohol. Naproxen can cause ulcers and bleeding in the stomach and intestines, and alcohol can increase the risk of these problems or may make them worse.
Chronic alcohol consumption can decrease the level of albumin (a protein) in the blood. Naproxen molecules normally bind to albumin and are not "active" as long as they are bound to albumin. With low albumin levels in the blood (which can occur with chronic alcoholic liver disease), a normal naproxen dosage can lead to increased naproxen toxicity, as more molecules are unbound and "active."
You should discuss combining alcohol and naproxen with your healthcare provider. You and your healthcare provider understand your situation best. Based on what you want and expect, as well as your current health situation, the two of you can make a shared decision about your intake of alcohol while on this drug. Keep in mind that there may be other medical reasons why you should not consume alcohol.