Naproxen Drug Interactions
More Information on Interactions With NaproxenThe following sections explain in detail the potentially negative interactions that can occur if naproxen is combined with any of the substances listed above.
Combining naproxen with an ACE inhibitor can increase the risk of kidney problems (especially in people that already have kidney problems) and can decrease the effectiveness of the ACE inhibitor for lowering blood pressure.
Combining naproxen with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.
Combining naproxen with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
Bile Acid Sequestrants
Bile acid sequestrants can bind to naproxen in the digestive tract and delay its absorption into the body. To avoid this drug interaction, naproxen should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
Using corticosteroids with naproxen can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
Naproxen may increase the level of cyclosporine in the blood, increasing the risk of serious side effects of cyclosporine. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
Naproxen may increase the level of digoxin in your bloodstream, increasing the risk of dangerous side effects of digoxin. If you are taking digoxin, check with your healthcare provider before starting or stopping naproxen.