More Information on Interactions With Naproxen
The following sections explain in detail the potentially negative interactions that can occur if
naproxen is combined with any of the substances listed above.
Warfarin (Coumadin, Jantoven)
If you are taking other blood thinners, such as warfarin, while taking naproxen, your body may metabolize them differently than intended. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust your dosages accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Using these pain relievers with naproxen can increase your risk of bleeding. However,
acetaminophen (
Tylenol®) products can be used safely in combination with naproxen.
Aspirin
Studies have indicated that the chances are higher for stomach ulcers when aspirin and naproxen are combined. Talk to your healthcare provider about using aspirin and naproxen together in your particular situation.
ACE Inhibitors (Accupril, Lotensin, Vasotec, Altace, Zestril, Prinivil, Monopril, Capoten)
Naproxen may inhibit the
blood pressure-lowering effects of ACE inhibitors. Your healthcare provider may need to adjust your dose of these drugs to prevent this interaction.
Diuretics (Torsemide [Demadex], Furosemide [Lasix], Hydrochlorothiazide)
Naproxen may reduce the activity of diuretics. Your healthcare provider may need to adjust your dose of these drugs to prevent this interaction.
Lithium (Eskalith, Lithane, Lithonate, Lithotabs)
Taking naproxen and
lithium together may increase the levels of lithium in your body by decreasing the removal of lithium by the kidneys. Your healthcare provider may need to adjust your doses of these drugs and monitor the level of lithium in your blood.