Drug Combinations With Naproxen to Avoid

Diuretics
Combining naproxen with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking naproxen and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining naproxen with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine naproxen with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Naproxen may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Combining probenecid and naproxen may increase the levels of naproxen in the blood. Therefore, your healthcare provider may recommend a lower naproxen dosage and monitor you more closely.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with naproxen may increase the risk of bleeding. Check with your healthcare provider before taking naproxen with an SSRI or SNRI.
 
Herbal and/or Nutritional Supplements
Several herbal and nutritional supplements can also interact with naproxen and may increase the risk of bleeding. If you are taking any natural or herbal supplements, make sure to discuss this with your healthcare provider before starting naproxen therapy.
  
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