When certain medicines (such as lithium or aspirin) are taken with naproxen, drug interactions may occur. Some interactions may cause serious side effects, such as increased risk of bleeding, stomach ulcers, or increased levels of naproxen in the blood. Other medications that can potentially cause naproxen drug interactions include other nonsteroidal anti-inflammatory drugs, cholestyramine, and beta blockers.
Naproxen (brand names include Aleve®, Naprosyn®, EC-Naprosyn®, Anaprox®, Anaprox® DS, and Naprelan®) has a number of medicines that it can potentially interact with. Some of these naproxen drug interactions include:
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others.
Several herbal and nutritional supplements can also interact with naproxen and may increase the risk of bleeding. Examples of these include, but are not limited to: