Naproxen Drug Interactions

When certain medicines (such as lithium or aspirin) are taken with naproxen, drug interactions may occur. Some interactions may cause serious side effects, such as an increased risk of bleeding, stomach ulcers, or increased levels of naproxen in the blood. Other medications that can potentially cause interactions include other NSAIDs, cholestyramine, and beta blockers.

Naproxen Drug

Naproxen Interactions: An Overview

Naproxen (brand names include Aleve^®, Naprosyn^®, EC-Naprosyn^®, Anaprox^®, Anaprox^® DS, and Naprelan^®) can potentially interact with a number of medicines. Some of the medicines that may cause naproxen drug interactions include:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil^®, Motrin^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), nabumetone (Relafen^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), meloxicam (Mobic^®), etodolac (Lodine^®), ketoprofen, ketorolac (Toradol^®), and others
Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), or hydrochlorothiazide

ACE inhibitors, such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), or ramipril (Altace^®)
Methotrexate (Rheumatrex^®, Trexall™)
Cholestyramine (Prevalite^®, Questran^®, Questran^® Light, LoCholest^®)
Beta blockers, such as metoprolol (Lopressor^®), propranolol (Inderal^®), atenolol (Tenormin^®), or metoprolol (Toprol XL^®)
Probenecid (Benemid^®, Probalan^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others.

Several herbal and nutritional supplements can also interact with naproxen and may increase the risk of bleeding. Examples of these include but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Naproxen Drug Interactions Continued: Page 2)