Naproxen (brand names include Aleve^®, Naprosyn^®, EC-Naprosyn^®, Anaprox^®, Anaprox^® DS, and Naprelan^®) can potentially interact with a number of medicines. Some of the medicines that may cause naproxen drug interactions include:

Angiotensin-converting enzyme inhibitors (ACE inhibitors), including:
- Benazepril (Lotensin^®), benazepril-hydrochlorothiazide (Lotensin HCT^®), or benazepril-amlodipine (Lotrel^®)
- Captopril (Capoten^®) or captopril-hydrochlorothiazide (Capozide^®)
- Enalapril (Vasotec^®), enalapril-hydrochlorothiazide (Vaseretic^®), or enalapril-felodipine (Lexxel^®)
- Fosinopril (Monopril^®) or fosinopril-hydrochlorothiazide (Monopril-HCT^®)
- Lisinopril (Prinivil^®, Zestril^®) or lisinopril-hydrochlorothiazide (Prinzide^®, Zestoretic^®)
- Quinapril (Accupril^®) or quinapril-hydrochlorothiazide (Accuretic^®, Quinaretic™)
- Ramipril (Altace^®)

Angiotensin II receptor blockers (ARBs), such as:

- Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
- Candesartan (Atacand^®) or candesartan-hydrochlorothiazide (Atacand HCT^®)
- Eposartan (Teveten^®) or eposartan-hydrochlorothiazide (Teveten^® HCT)
- Irbesartan (Avapro^®) or irbesartan-hydrochlorothiazide (Avalide^®)
- Losartan (Cozaar^®) or losartan-hydrochlorothiazide (Hyzaar^®)
- Olmesartan (Benicar^®), olmesartan-hydrochlorothiazide (Benicar HCT^®), or amlodipine and olmesartan (AZOR™)
- Telmisartan (Micardis^®) or telmisartan-hydrochlorothiazide (Micardis^® HCT)
- Valsartan (Diovan^®) or valsartan-hydrochlorothiazide (Diovan HCT^®)

Beta blockers, such as:
- Acebutolol (Sectral^®)
- Atenolol (Tenormin^®)
- Betaxolol (Kerlone^®)
- Bisoprolol (Zebeta^®)
- Carvedilol (Coreg^®, Coreg CR^®)
- Esmolol (Brevibloc^®)
- Labetalol (Trandate^®)
- Metoprolol (Lopressor^®, Toprol-XL^®)
- Nadolol (Corgard^®)
- Nebivolol (Bystolic^®)
- Penbutolol (Levatol^®)
- Propranolol (Inderal^®, Inderal^® LA, InnoPran XL™)
- Sotalol (Betapace^®)
- Timolol

Bile acid sequestrant cholesterol medications, including:
- Cholestyramine (Prevalite^®, Questran^®, Questran^® Light)
- Colesevelam (WelChol^®)
- Colestipol (Colestid^®)

Corticosteroids, including (but not limited to):
- Betamethasone (Celestone^®)
- Cortisone
- Dexamethasone (Decadron^®)
- Fludrocortisone (Florinef^®)
- Hydrocortisone (Cortef^®)
- Methylprednisolone (Depo-Medrol^®, Medrol^®)
- Prednisolone (Orapred^®, Pediapred^®)
- Prednisone
- Triamcinolone (Kenalog^®, Aristospan^®)

Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Digoxin (Digitek^®, Lanoxin^®)
Diuretics, such as:
- Amiloride (Midamor^®) or amiloride-HCTZ (Moduretic^®)
- Bumetanide (Bumex^®)
- Chlorothiazide (Diuril^®)
- Chlorthalidone (Thalitone^®)
- Ethacrynic acid (Edecrin^®)
- Furosemide (Lasix^®)
- Hydrochlorothiazide (Esidrix^®, HydroDIURIL^®, Microzide^®, Oretic^®)
- Metolazone (Zaroxolyn^®)
- Spironolactone (Aldactone^®) or spironolactone-HCTZ (Aldactazide^®)
- Torsemide (Demadex^®)
- Triamterene (Dyrenium^®) or triamterene/HCTZ (Dyazide^®, Maxzide^®)

Lithium (Eskalith^®, Lithobid^®)
Medications that "thin" the blood or otherwise increase bleeding risk (such as anticoagulant and antiplatelet drugs), such as:
- Antithrombin (ATryn^®, Thrombate III^®)
- Apixaban (Eliquis^®)
- Argatroban
- Aspirin (Bayer^® and others)
- Bivalirudin (Angiomax^®)
- Cilostazol (Pletal^®)
- Clopidogrel (Plavix^®)
- Dabigatran (Pradaxa^®)
- Dipyridamole (Persantine^®)
- Drotrecogin alfa (Xigris^®)
- Eptifibatide (Integrilin^®)
- Fondaparinux (Arixtra^®)
- Heparin or heparin-like products, including dalteparin (Fragmin^®), enoxaparin (Lovenox^®), or tinzaparin (Innohep^®)
- Lepirudin (Refludan^®)
- Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

- - Celecoxib (Celebrex^®)
  - Diclofenac (Cambia™, Cataflam^®, Flector^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
  - Etodolac (Lodine^®, Lodine^® XL)
  - Ibuprofen (Motrin^®, Advil^®, Nuprin^®)
  - Indomethacin (Indocin^®, Indocin SR^®)
  - Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
  - Ketorolac (Toradol^®)
  - Meloxicam (Mobic^®)
  - Nabumetone (Relafen^®)
  - Oxaprozin (Daypro^®)
  - Piroxicam (Feldene^®)
  - Others (see List of NSAIDs for a more complete list of these medications)

- Pentoxifylline (Trental^®)
- Prasugrel (Effient^®)
- Rivaroxaban (Xarelto^®)
- Thrombolytics, such as:

- - Alteplase (Activase^®)
  - Reteplase (Retavase^®)
  - Streptokinase (Streptase^®)
  - Tenecteplase (TNKase^®)

- Ticagrelor (Brilinta^®)
- Ticlopidine (Ticlid^®)
- Tirofiban (Aggrastat^®)
- Warfarin (Coumadin^®, Jantoven^®)

Methotrexate (Rheumatrex^®, Trexall^®)
Probenecid (Benemid^®, Probalan^®)
SSRI or SNRI medications, including:
- Citalopram (Celexa^®)
- Duloxetine (Cymbalta^®)
- Desvenlafaxine (Pristiq^®)
- Escitalopram (Lexapro^®)
- Fluoxetine (Prozac^®, Sarafem^®, Selfemra™)
- Fluvoxamine (Luvox^®, Luvox^® CR)
- Levomilnacipran (Fetzima™)
- Milnacipran (Savella™)
- Paroxetine (Paxil^®, Paxil CR^®, Pexeva^®, Brisdelle™)
- Sertraline (Zoloft^®)
- Venlafaxine (Effexor^®, Effexor XR^®).

Several herbal and nutritional supplements can also interact with naproxen and may increase the risk of bleeding. Examples of these include but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

Naproxen Drug Interactions Article Continues on Next Page >

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD

Last reviewed by: Kristi Monson, PharmD

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