Safety Concerns With Naproxen

Side Effects of Naproxen

As with any medicine, side effects are possible with naproxen. However, not everyone who takes the drug will experience side effects. Most people tolerate it well. If side effects do occur, in many cases, they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
 
Common side effects may include:
 
  • Heartburn
  • Stomach pain
  • Nausea
  • Constipation
  • Headache
  • Dizziness
  • Drowsiness
  • Itching
  • Unexplained rash
  • Ringing in the ears (tinnitus)
  • Shortness of breath
  • Fluid retention.
     
(Click Naproxen Side Effects to learn more, including potentially serious side effects you should report to your healthcare provider.)
 

Drug Interactions

Naproxen can potentially interact with several different medications (see Naproxen Drug Interactions for more information).
 

What Should I Tell My Healthcare Provider Before Taking Naproxen?

The U.S. Food and Drug Administration (FDA) warns that people using NSAIDs (other than aspirin), including naproxen, may have a higher risk of having a heart attack or stroke than those who do not. This risk may be higher in people who have been taking NSAIDs for a long time. These events can occur without any warning and can lead to death. Be sure to tell your healthcare provider if you have or ever have had any of the following:
 
Prior to taking naproxen, you should also tell your healthcare provider if you have:
 
  • Asthma
  • Congestive heart failure
  • Liver disease or liver failure
  • Kidney disease or kidney failure
  • Bleeding problems or are taking medicines that decrease your blood's ability to clot
  • Diabetes
  • Stomach ulcers, stomach bleeding, or a history of either condition
  • Any allergies to medicines, including sulfa drugs, aspirin, or other NSAID pain medicines.
     
Also, let your healthcare provider know if you:
 
  • Are pregnant or thinking about becoming pregnant (see Naproxen and Pregnancy)
  • Are breastfeeding
  • Drink alcohol frequently
  • Smoke
  • Are having or have recently had heart surgery.
     
In addition, tell your healthcare provider about all other medicines you may currently be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Naproxen Precautions and Warnings for more information, including information on who should not take the drug.)
 
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