How NSAIDs Work and Pediatric and Off-Label Indications

How Do NSAIDs Work?

NSAIDs are thought to work by inhibiting the action of certain hormones that cause inflammation and pain in the body. These hormones are called prostaglandins. By blocking the effects of prostaglandins, NSAIDs are useful at reducing fever and pain related to a number of conditions. This includes pain and joint swelling associated with different forms of arthritis and other conditions and pain related to inflammation or bone, muscle, or tendon injury.

Are NSAIDs Used in Children?

Specific NSAID formulations have been designed for use in infants and children.

Are There Any Off-Label Uses for NSAIDs?

On occasion, your healthcare provider may recommend NSAIDs for something other than the conditions discussed in this article. This is called an "off-label" use. Some off-label NSAIDs uses include the treatment of:
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