Pennsaid and Pregnancy

NSAIDs and Pregnancy Complications

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). Even though it is applied to the skin, some of the medication is absorbed into the bloodstream and passed through the placenta to the fetus. Studies have demonstrated that NSAIDs can cause certain problems during pregnancy in humans, including:
  • Increased risk of miscarriage
  • Possible increased risk of birth defects, although this risk appears to be small
  • Prolonged pregnancy, since NSAIDs inhibit the prostaglandins that help stimulate labor
  • Poor kidney function in the fetus
  • Premature closure of the ductus arteriosus (a potentially fatal heart problem) in the fetus
  • Persistent pulmonary hypertension (a serious lung problem) in the newborn.
The most serious adverse effects of NSAID use occur near the end of pregnancy. In addition, women trying to become pregnant should avoid NSAIDs, since they appear to interfere with the implantation process.

Pregnancy and Pennsaid: Final Thoughts

If you are pregnant or thinking about becoming pregnant, let your healthcare provider know. Your healthcare provider will consider both the benefits and risks of using Pennsaid during pregnancy before making a recommendation in your particular situation.
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