Pennsaid Drug Interactions

ACE inhibitors, aspirin, and lithium are just a few of the drugs that can interact with Pennsaid. Several problems can occur as a result of these and other interactions with the NSAID medication, including kidney damage, reduced drug effectiveness, and increased risk of side effects. To reduce your risk, tell your healthcare provider about all other medications you are taking.

An Overview of Interactions With Pennsaid

Even though Pennsaid® (diclofenac sodium topical solution) is applied to the skin, it can potentially interact with several other medications, since some Pennsaid is absorbed into the bloodstream. Some of the products that may lead to Pennsaid drug interactions include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with Pennsaid and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Top Foods to Fight Inflammation

Pennsaid Medication Information

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