Taking Piroxicam With Other Medications

Diuretics
Combining piroxicam with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking piroxicam and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining piroxicam with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine piroxicam with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Piroxicam may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of piroxicam in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with piroxicam may increase the risk of bleeding. Check with your healthcare provider before taking piroxicam with an SSRI or SNRI.
 
Herbal and/or Nutritional Supplements
Several herbal and nutritional supplements can also interact with piroxicam and may increase the risk of bleeding. If you are taking any natural or herbal supplements, make sure to discuss this with your healthcare provider before starting piroxicam therapy.
  
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