When medicines such as antacids or diuretics are taken together with Ponstel, drug interactions may potentially occur. Some interactions may decrease the effectiveness of the drugs or increase Ponstel levels in the blood, while others may cause side effects such as kidney damage, bleeding, or stomach ulcers. Other medicines that may potentially lead to Ponstel drug interactions include cyclosporine, beta blockers, and angiotensin II receptor blockers.
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and many others
Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
Antacids, including Maalox®, Mylanta®, Riopan®, Gelusil®, and others.
Several herbal and nutritional supplements can also interact with Ponstel and may increase the risk of bleeding. Examples of these include, but are not limited to: