Taking Sulindac With Other Medications

More Information on Sulindac Drug Interactions

The following sections explain in detail how the drugs mentioned above can cause negative interactions when taken with sulindac.
 
ACE Inhibitors
Combining sulindac with an ACE inhibitor can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ACE inhibitor for lowering blood pressure.
 
ARBs
Combining sulindac with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.
 
Beta Blockers
Combining sulindac with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to sulindac in the digestive tract and delay its absorption into the body. To avoid this drug interaction, sulindac should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
 
Corticosteroids
Using corticosteroids with sulindac can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
 
Cyclosporine
Sulindac may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
 
Digoxin
Sulindac may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping sulindac.
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Sulindac Info

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