Drug Interactions With Sulindac

When certain medications are taken together, it is possible to develop drug interactions. With sulindac, some of the medications that can lead to interactions include angiotensin II receptor blockers, cyclosporine, and other nonsteroidal anti-inflammatory drugs. Besides decreasing the medicines' effectiveness, these interactions may cause side effects such as kidney damage, bleeding, or stomach ulcers. If drug interactions are a concern in your situation, your healthcare provider may adjust your dosages or monitor you more closely.

Sulindac Info

Interactions With Sulindac: An Overview

Sulindac (Clinoril^®) can potentially interact with several different medicines. Some of these medications include the following:

Warfarin (Coumadin^®, Jantoven^®)
Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Motrin^®, Advil^®), naproxen (Naprosyn^®), naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®), diclofenac (Cataflam^®, Voltaren^®), indomethacin (Indocin^®), nabumetone (Relafen^®), oxaprozin (Daypro^®), celecoxib (Celebrex^®), meloxicam (Mobic^®), etodolac (Lodine^®), ketoprofen, ketorolac (Toradol^®), and others
Aspirin
Lithium (Eskalith^®, Lithane^®, Lithonate^®, Lithotabs^®)
Diuretics, such as torsemide (Demadex^®), furosemide (Lasix^®), and hydrochlorothiazide
ACE inhibitors, such as lisinopril (Zestril^®, Prinivil^®), fosinopril (Monopril^®), captopril (Capoten^®), quinapril (Accupril^®), benazepril (Lotensin^®), enalapril (Vasotec^®), or ramipril (Altace^®)
Angiotensin II receptor blockers (ARBs), including losartan (Cozaar^®), valsartan (Diovan^®), irbesartan (Avapro^®), telmisartan (Micardis^®), or candesartan (Atacand^®)
Methotrexate (Rheumatrex^®, Trexall™)
Beta blockers, such as metoprolol (Lopressor^®), propranolol (Inderal^®), atenolol (Tenormin^®), or metoprolol (Toprol XL^®)
Corticosteroids, such as prednisone, hydrocortisone (Cortef^®), dexamethasone (Decadron^®, Dexone^®, Hexadrol^®), and many others
Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
Diflunisal (Dolobid^®)
Probenecid (Benemid^®, Probalan^®).

Several herbal and nutritional supplements can also interact with sulindac and may increase the risk of bleeding. Examples of these include, but are not limited to:

Dong quai
Feverfew
Garlic
Ginger
Ginkgo biloba
Ginseng
St. John's wort
Fish oil supplements.

(Drug Interactions With Sulindac Continued: Page 2)