When certain medications are taken together, it is possible to develop negative drug interactions. With sulindac, these medicines may include angiotensin II receptor blockers, cyclosporine, and other nonsteroidal anti-inflammatory drugs. Besides decreasing the medicines' effectiveness, these interactions may cause side effects such as kidney damage, bleeding, or stomach ulcers. If drug interactions with sulindac are a concern, your healthcare provider may adjust your dosages or monitor you more closely.
Several herbal and nutritional supplements can also interact with sulindac and may increase the risk of bleeding. Examples of these include, but are not limited to: