More Safety Info on Sulindac

Specific Precautions and Warnings With Sulindac

Issues to be aware of prior to starting sulindac include the following:
 
  • Certain medications can interact negatively with sulindac (see Drug Interactions With Sulindac).
     
  • All NSAIDs (nonsteroidal anti-inflammatory drugs), including sulindac, have been reported to cause cardiovascular events, such as a heart attack or stroke, which can result in loss of life. People with cardiovascular disease or who have cardiovascular risk factors appear to be at greater risk. To decrease the chances of developing these problems, you should take the smallest effective dose for the shortest period of time. Call 911 if you notice:
 
    • Chest pain
    • Shortness of breath
    • Weakness
    • Slurring of speech.
 
  • All NSAIDs, including sulindac, may cause high blood pressure or make it worse. Therefore, sulindac should be used with caution in people with known high blood pressure.
     
  • All NSAIDs, including sulindac, may cause congestive heart failure or swelling. Contact your healthcare provider right away if you notice unexplained weight gain or swelling. Also, sulindac should be used with caution in people with heart failure.
     
  • All NSAIDs, including sulindac, have been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines (called perforations). These problems can lead to serious complications or even loss of life. Extreme caution should be used if sulindac is prescribed for people with a history of ulcers or gastrointestinal bleeding. To decrease the chances of developing these problems, you should take the smallest effective dose for the shortest period of time. Contact your healthcare provider immediately if you experience any signs or symptoms of stomach ulcers or bleeding, including:
 
    • Stomach pain
    • Indigestion
    • Black, tarry stools
    • Vomiting blood.
 
  • Kidney damage can happen in people taking NSAIDs as well, including sulindac. It is more common in people with kidney disease, heart failure, liver problems, those taking a diuretic or ACE inhibitor, and the elderly.
     
  • Liver damage can occur in people who are taking sulindac. Contact your healthcare provider immediately if you notice:
 
    • Nausea
    • Tiredness
    • Lethargy
    • Itchy or yellowing skin
    • Abdominal pain
    • Flu-like symptoms.
 
  • NSAIDs, including sulindac, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice:
 
    • Hives
    • Unexplained rash
    • Difficulty breathing
    • Swelling of the face and throat.
 
  • In rare cases, people taking sulindac can develop a very serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking the sulindac and call your healthcare provider.
     
  • Cases of renal stones have been reported rarely in people taking sulindac. Therefore, you should stay well hydrated while taking this medication.
     
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting sulindac. Alcohol can affect the way the liver works, indirectly affecting the way sulindac works.
     
  • NSAIDS have been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting sulindac and then again 12 weeks after treatment has started.
     
  • Sulindac has been known to cause anemia. Therefore, if you are taking sulindac for an extended amount of time and show signs of anemia, talk to your healthcare provider.
     
  • Problems with vision have been reported in people taking sulindac. If you notice any changes in your vision, such as blurry vision or changes in color vision, contact your healthcare provider.
     
  • You should not take sulindac with any other NSAIDs, since this may increase your risk for any of the problems discussed above. Many NSAIDs are available without a prescription, so read labels carefully. Examples of NSAIDs include:
 
 
  • Sulindac is a pregnancy Category C medicine, meaning that it could potentially cause harm to your unborn child. If you are pregnant, you should only take sulindac if the benefit outweighs the possible risk to the fetus. Sulindac is not recommended for women in the third trimester of pregnancy because it can cause injury and even death to the developing fetus. If you become pregnant while taking sulindac, contact your healthcare provider immediately (see Clinoril and Pregnancy for more information).
     
  • If you are nursing, it is recommended that you do not take sulindac. Therefore, if you are taking sulindac and nursing, ask your healthcare provider whether to stop nursing or discontinue the medicine.
     
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Sulindac Info

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