Side Effects of Sulindac

Common sulindac side effects include constipation, stomach pain, nausea, and decreased appetite. Rare side effects (occurring in less than 1 percent of people) include muscle weakness, vision problems, and insomnia. If you experience more side effects, such as stomach or intestinal problems, allergic reactions, or congestive heart failure, notify your healthcare provider immediately.

An Introduction to Side Effects of Sulindac

As with any medicine, side effects are possible with sulindac (Clinoril®). However, not everyone who takes the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, they are generally minor and either require no treatment or can be easily treated by you or your healthcare provider.
Several factors affect the chances of developing side effects of sulindac, including:
  • Your sulindac dosage
  • Your age
  • Other medical conditions
  • Other medications you are taking.
(This article covers many, but not all, of the possible side effects with sulindac. Your healthcare provider can discuss a more complete list of side effects with you.)

Serious Sulindac Side Effects

The U.S. Food and Drug Administration (FDA) warns that people using nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin, including sulindac, may be at higher risk for heart attack or stroke than those who do not take NSAIDs. This risk may be higher in people who have been taking NSAIDs for a long time. These events can occur without warning and can lead to loss of life. Call 911 if you experience any of the following symptoms:
  • Chest pain
  • Shortness of breath
  • Weakness on one part of your body
  • Slurred speech.
Other potentially serious side effects include, but are not limited to:
  • Allergic reactions, such as:
    • Swelling of the face or body
    • Blisters
    • Unexplained skin rash
    • Wheezing
    • Difficulty breathing
  • Stomach or intestinal problems, including:
    • Bleeding
    • Ulcers
    • A hole (known as a perforation)
  • Liver damage, which can cause:
    • Nausea
    • Fatigue
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Excessive tiredness
Because sulindac can increase the risk of major or life-threatening bleeding, contact your healthcare provider immediately if you notice any unusual bleeding or have any of the following symptoms:
  • Bloody nose
  • Black, tarry stools
  • Blood in the urine or stools
  • Vomiting blood
  • Red or purple spots on the skin.
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Sulindac Info

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