Synvisc Warnings and Precautions

Before you start using Synvisc, precautions and warnings for the product should be discussed with your healthcare provider. If you are allergic to any bird products, you may also be allergic to Synvisc because it is made from chicken combs. You should avoid using this product if you have a knee infection or any infection or disease in the skin area around the injection site.

What Should I Tell My Healthcare Provider Before Taking Synvisc?

You should talk with your healthcare provider prior to taking Synvisc® (hylan G-F 20) if you have:
  • A swollen leg, ankle, or foot
  • An infection in or around the knee
  • Any allergies, including allergies to food, dyes, or preservatives.
Let your healthcare provider know if you are:
  • Pregnant or thinking about becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Synvisc Warnings and Precautions

Warnings and precautions to be aware of prior to taking Synvisc include the following:
  • If you are allergic to any bird products, such as feathers or eggs, you might also be allergic to Synvisc, since it is made from chicken combs.
  • Your healthcare provider should not inject any medications (such as steroids or anesthetics) into the knee joint along with Synvisc, as this would dilute Synvisc and make it less effective. It is okay for your healthcare provider to inject a local anesthetic to help numb the area prior to the injection.
  • In the United States, Synvisc is not approved for injection into any other joint except the knees.
  • This product should not be injected into the bloodstream or anywhere else except the knee joint.
  • Synvisc should be used with caution if you have swelling of the leg, ankle, or foot.
  • It is unknown if Synvisc passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Synvisc and Breastfeeding).
  • It is not known if Synvisc is safe for use during pregnancy (see Synvisc and Pregnancy).
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