Tylenol Drug Interactions

When alcohol, cholestyramine, or barbiturates are taken together with Tylenol, drug interactions may occur. Many of these medications can affect the way your body handles Tylenol, making both drugs less effective and more toxic. Tylenol interactions may also occur if you take other products containing acetaminophen (the active ingredient in Tylenol); you should not take more than 4000 mg total of acetaminophen per day.

 

Tylenol Drug Interactions: An Overview

Tylenol® (acetaminophen) can potentially interact with other medications. Some of these medicines that may lead to Tylenol drug interactions include:
 
  • Alcohol
  • Barbiturates, such as:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
o Anexia®
o Dolorex Forte®
o Hycet™
o Liquicet™
o Lorcet® and Lorcet® Plus
o Lortab®
o Margesic-H™
o Norco®
o Vicodin®, Vicodin® ES, and Vicodin® HP
o Xodol®
o Zydone®
  • Isoniazid (Nydrazid®)
  • Many non-prescription cough, cold, and allergy products
  • Many non-prescription menstrual medications (such as Midol®)
  • Oxycodone and acetaminophen (Endocet®, Magnacet™, Narvox®, Percocet®, Perloxx®, Roxicet®, Tylox®)
  • Propoxyphene and acetaminophen (Balacet 325™, Darvocet®)
  • Tramadol and acetaminophen (Ultracet®)
  • Warfarin (Coumadin®, Jantoven®).
     
(Tylenol Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;