Treatment Instructions for Xarelto

When and How to Take It

Some general considerations to keep in mind during treatment with Xarelto include the following:
  • For use after surgery, this medication is taken by mouth just once a day for a certain period of time after surgery (12 to 35 days, depending on the type of surgery). If you are taking the standard dose of 10 mg daily, you may take this medication with or without food. If you are taking the higher dosages (15 or 20 mg daily), you must take it with food.


  • For use in people with atrial fibrillation, this medication is taken once a day, with the evening meal, on an ongoing basis.
  • For treating existing blood clots (while preventing future blood clots at the same time), the drug is taken twice a day initially (with food), then switched to once a day (with food). The length of treatment will be determined by your healthcare provider, depending on your risk factors for future clots.


  • Try to take Xarelto at the same time each day to keep an even level of the drug in your bloodstream.
  • Both the 15- and 20-mg Xarelto tablets can be crushed if you have difficulty swallowing medications. Crush each tablet right before you take your dose and mix with applesauce before swallowing. The crushed tablets may also be mixed with water when given through a feeding tube. You will still need to take your dose with food, even though the crushed tablet is taken with applesauce. The 10-mg tablets should be swallowed whole.


  • For this drug to work properly, it must be taken as prescribed. You may be increasing your risk for serious problems if you stop taking it too soon.

Dosing Information

The dose your healthcare provider recommends will vary, depending on why you are taking the medication, the type of surgery you had, and if you are taking any other medications that interact with Xarelto. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Xarelto Dosage for more information.)
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Xarelto Drug Information

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