Xarelto Side Effects

Some potentially serious bleeding problems can occur while taking Xarelto. Contact your healthcare provider right away if you develop problems like unusual bruising, blood in the urine, or coughing up blood. In most cases, side effects of Xarelto tend to be minor and easily treated. Common reactions may include itching, elevated liver enzymes, and back pain.

An Introduction to Xarelto Side Effects

Just like any medicine, Xarelto® (rivaroxaban) can cause side effects. However, not everyone who uses the medication will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Xarelto. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Xarelto

Xarelto has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking Xarelto were documented and compared to those that occurred in a similar group of people taking enoxaparin (Lovenox®). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the group taking enoxaparin.
In these studies, common Xarelto side effects included:
  • Any bleeding (including major and minor bleeding) -- in up to 28.3 percent of people
  • Elevated liver enzymes (found using a blood test) -- up to 6.6 percent
  • Back pain -- up to 3.7 percent
  • Elevated bilirubin levels (found using a blood test) -- up to 3.2 percent
  • Bleeding in the digestive tract (gastrointestinal bleeding) -- up to 3.1 percent 
  • Fluid leaking from in or around the surgical incision -- up to 2.8 percent
  • Itching -- up to 2.1 percent
  • Low blood platelets (found using a blood test) -- up to 2.6 percent.
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Xarelto Drug Information

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