Gengraf and Psoriatic Arthritis

Although the drug is not approved for this use, Gengraf may be given "off-label" to treat psoriatic arthritis. It can provide relief from symptoms and may also slow down the progression of the disease; however, Gengraf is not a cure. In addition, there is the potential for dangerous side effects, so talk to your healthcare provider to make sure it is right for you.

What Is Psoriatic Arthritis?

Psoriatic arthritis is a type of inflammatory arthritis that affects people with psoriasis, a skin condition characterized by thickened, red, scaly areas of skin. Most people with psoriatic arthritis will develop psoriasis first.
People with this condition may experience:
  • Pain, tenderness, and swelling of the joints
  • Stiffness of the joints, especially in the morning
  • Fatigue.


Psoriatic arthritis can also cause inflammation in other areas of the body, such as the eyes, kidneys, or lungs.


Can Psoriatic Arthritis Be Treated With Gengraf?

Gengraf® (cyclosporine) is one of several possible treatment options available for psoriatic arthritis. It is in a class of medicines called disease-modifying antirheumatic drugs (DMARDs). DMARDs are used to try to slow down the progression of this disease.
Interestingly, even though Gengraf is sometimes used to treat psoriatic arthritis, it is not officially approved for this use. Gengraf is approved to treat severe rheumatoid arthritis and severe psoriasis. It is also approved to prevent transplant rejection (when the immune system attacks a transplanted organ) after a kidney, liver, or heart transplant.
Keep in mind, however, that just because this medication does not have approval from the U.S. Food and Drug Administration (FDA) for treating psoriatic arthritis, this does not mean Gengraf can't be used for this condition. This is just considered an "off-label" use. Many medications are used off-label when they have been shown to be effective for conditions, but for various reasons, the manufacturer has not sought an official approval from the FDA.
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