Arthritis Home > Gengraf

The prescription drug Gengraf is used to suppress the body's immune system, which makes it useful after organ transplant surgery or to relieve symptoms of rheumatoid arthritis and psoriasis when other treatments have failed. The medication comes in both capsule and liquid forms, and is generally taken twice a day. Side effects may include high blood pressure and kidney problems.

What Is Gengraf?

Gengraf® (cyclosporine) is a prescription immunosuppressant medication approved to prevent organ rejection after kidney, heart, or liver transplants. It is also approved to treat rheumatoid arthritis and psoriasis, when the conditions are severe and have not adequately responded to other treatments.
Gengraf is a generic form of Neoral®. Medications like Gengraf that have brand names but are generic versions of other products, are sometimes called "branded generics."
Like Neoral, Gengraf is a modified form of cyclosporine. It has been slightly changed from original cyclosporine (Sandimmune®) to be more easily absorbed by the body. Because they are absorbed differently, modified cyclosporine and original cyclosporine are not interchangeable.
(Click Gengraf Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Gengraf is made by Abbott Laboratories.

How Does Gengraf Work?

Gengraf is an "immunosuppressant" medication -- it works by making the immune system less active. An overactive immune system is involved in rheumatoid arthritis and psoriasis. Transplant rejection occurs when the body's immune system sees the transplanted organ as a foreign material and attacks it. By suppressing the immune system, Gengraf can help prevent transplant rejection and ease symptoms of rheumatoid arthritis and psoriasis.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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