Arthritis Home > Naproxen Sodium Side Effects

Drowsiness, nausea, stomach pain, and heartburn are some common side effects reported with naproxen sodium. Side effects that are less common can include vision or hearing problems, hepatitis, and depression. Some side effects require immediate medical attention. Notify your healthcare provider if you develop slurred speech, vomiting blood, or wheezing, among other serious side effects.

An Introduction to Naproxen Sodium Side Effects

As with any medicine, side effects are possible with naproxen sodium (brand names include Aleve®, Anaprox®, and Naprelan®). However, not everyone who takes the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, they are generally minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with naproxen sodium. Your healthcare provider can discuss a more complete list of side effects with you.)

Common Side Effects of Naproxen Sodium

Naproxen sodium has been studied extensively in clinical trials, with thousands of people worldwide having been evaluated. In these studies, side effects are always documented and compared to those that occurred in a similar group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the drug.
Based on these studies, the most common naproxen sodium side effects (occurring in more than 3 percent of people) include:
  • Heartburn
  • Stomach pain
  • Nausea
  • Constipation
  • Headache
  • Dizziness
  • Drowsiness
  • Itching
  • Unexplained rash
  • Ringing in the ears
  • Shortness of breath
  • Fluid retention.
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Last reviewed by: Kristi Monson, PharmD;
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